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Urinary Estrogen Ratio Test

Estrogens are hormones that are produced in both men and women. Estrogens in the blood stream will eventually be broken down by the liver into estrogen metabolites which are then excreted in the urine. There are many different routes that estrogen can take on its way out of the body. Two of the major metabolites are 2-hydroxyestrone (2-OHE1) and 16-alpha-hydroxyestrone (16-OHE1). There has been a growing body of research that demonstrates that having a ratio to 2-OHE1 to 16-OHE1 greater than 2.0 is associated with a lower disease risk and may help to preserve good health.

Conditions that have been associated with an imbalance in estrogen metabolism include:

  • Breast Cancer
  • Cervical Dysplasia
  • Recurrent Respiratory Papillomatosis (RRP)
  • Prostate Cancer

Deciding to do the testing to know your ratio can give you an indication of your relative risk of developing these conditions or your likelihood of a recurrence. By being proactive and knowing where your estrogen metabolism is today, you can make the necessary changes in order to improve your ratio and reduce your risk factors.